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This phenomenon, called cross-protection, was first observed in tobacco plants infected with a light-green mosaic virus that showed tolerance to re-inoculation with a yellow mosaic virus, whereas such protection was not observed when a dark-green mosaic virus was administered as the first inoculant (McKinney 1929)

Lane Limited Edgeworth Sliced Edgeworth Sliced was introduced on the American market in 1903

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Food and Drug Administration (FDA) concluded that the cooling and numbing sensation produced by menthol reduces the harshness of smoking, which may increase the appeal of smoking