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In our cEDS cohort, cardiovascular dysautonomia, although not particularly frequent, can explain orthostatic intolerance, palpitations, and tachycardia as well as some neurological secondary manifestations including fatigue, mood swings, and memory and concentration troubles

The addictive properties of tobacco primarily stem from nicotine, which rapidly reaches the brain upon inhalation or absorption through the mucous membranes, according to an article by the Food and Drug Administration 2024, titled Nicotine Is Why Tobacco Products Are Addictive Once in the brain, nicotine binds to nicotinic acetylcholine receptors, stimulating the release of neurotransmitters, including dopamine, which creates pleasurable sensations and reinforces the behavior of tobacco use

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