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Male and female homozygous 3xTg-AD mice and their non-transgenic littermates were obtained from The Jackson Laboratory (Bar Harbor, ME, USA) and were bred and maintained at the vivarium with food and water available ad libitum

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The alkene C = C stretching vibration, which appeared at 1643 cm in DNAzymes, shifted to 1663 cm in DNZ-NLPs, further confirming the incorporation of DNAzymes

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