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Although AR-targeted therapies have been effective in the early stages, the emergence of CRPC is associated with adaptive changes, including increased glutamine utilization

The present results are consistent with Farahat and colleagues , who studied efficacy of topical glutathione cream 2% and reported poor response and Sriharsha and colleagues , who used glutathione soap for 3 months in melasma treatment and reported no significant improvement in the hyperpigmentation in most patients

Over time, this reduction becomes visible not just on the skin, but across multiple systems that rely on collagen for resilience

A.BaratasA.de la CasaM.et al (2023)