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The improvement in energy is often noticeable because the body is able to quickly absorb the vitamin directly into the bloodstream, bypassing any digestive absorption issues

The multifaceted mechanism of action of 5FU involves direct incorporation of its metabolites into DNA (FdUTP) and RNA (FUTP), as well as inhibition of thymidylate synthase (TS) via FdUMP 4,5 , making it more difficult to identify rational combination partners that would enhance clinical responses without eliciting adverse systemic toxicity

The damage reduces bioactivity and is not reversible when the solution thaws

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