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Despite advances in chemotherapy, radiotherapy, and targeted therapies, challenges such as poor drug accumulation, systemic toxicity, and multidrug resistance persist, partly due to elevated intracellular GSH levels that neutralize reactive therapeutics and reduce treatment response

Neither compound has been evaluated or approved by the FDA for any use

Hyperuricemia-induced microbial dysbiosis increases L-kynurenine levels, which activates AHR pathway in renal tissue and promotes fibrosis [113]

Although chemically stable, it has a significant impact on neurological and biochemical processes, particularly through its interaction with vitamin B12 (Vit B12)