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Clinical investigations of Pycnogenol supplementation for twelve weeks in women aged 55 to 68 years found increased hyaluronic acid synthase mRNA levels by 44% and collagen type 1 mRNA levels by 40% in skin biopsies (25)

Clin Infect Dis (2021) 73(12):222839

International journal of molecular sciences, 24(8), 7445