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Trypanosomes exhibit several features of eukaryotic cell apoptosis, including loss of mitochondrial membrane potential, cytochrome c release, cell shrinkage, and DNA fragmentation, although the exact mechanisms involved in PCD of trypanosomatids and its biological relevance is still under debate (De Souza et al., 2019)

Mancini S, Nardo L, Gregori M, Ribeiro I, Mantegazza F, Delerue-Matos C, et al

Fukaya, Y

The cellular and molecular mechanisms that determine the functional polarity of reactive astrocytes remain incompletely understood and are probably regulated by complex, context-dependent signaling networks 2,3