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Importantly, although these analyses were performed at an Ab 46 -D-Glu 20 concentration similar to the therapeutic concentrations employed above, more extensive dosing studies suggest that D-Glu 20 does not saturate adsorption sites on fracture surfaces until at least 10,000 times this concentration

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2.1.1 Monoamine transporter disruption and neurotransmitter release METH disrupts the reuptake and enhances the release of dopamine, serotonin, and norepinephrine, significantly increasing their extracellular concentrations