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Each and every cell in our body has the capability to make glutathione on its own according to its metabolic demands. - Shalin Kochar Why Glutathione Levels May Decline Over Time Glutathione demand appears to increase in response to cumulative physiologic stress

On the other hand, oxidative stress leads to mtDNA damage, the damaged mtDNA will exacerbate ROS production, thus aggravating oxidative stress, and forming a vicious cycle

For people who look outwardly functional but still feel emotionally and physically weighed down, this article on working with functional depression describes a pattern I see often