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The total period of study was 1 month

The protocol for the collection of these cells from human volunteers was approved by the University of North Carolina at Chapel Hill Institutional Review Board and the US Environmental Protection Agency Office of Human Research Protection

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In drawing on studies that extend from clinical epidemiology, through genetics, pharmacotherapy and animal models, to cell biology and biochemistry, we have aimed to provide a comprehensible and accessible narrative, although this comes at the expense of a fully comprehensive and systematic (and inevitably longer) analysis