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In preclinical models, ERR activation: Stimulates expression of genes associated with aerobic exercise adaptation Enhances mitochondrial biogenesis and oxidative respiration Increases fatty acid oxidation in skeletal and cardiac muscle Supports endurance capacity and metabolic flexibility Because of these effects, the compound has been described in the literature as an exercise mimetic a molecule that may reproduce certain biochemical signatures of physical training without the training stimulus itself

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B12 supplementation has been reported to help with fatigue and nausea that semaglutide users commonly experience, though the evidence for this is largely anecdotal rather than clinical

This makes it potentially suitable for individuals with insulin resistance, pre-diabetes, or type 2 diabetes, populations who would not be good candidates for growth hormone therapy due to its glucose-elevating effects