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Underexplored epigenetic and long-term regulatory mechanisms: Epigenetic regulation of ferroptosis in AKI-to-CKD transition is largely limited to individual molecules (e.g., miRNAs targeting GPX4), with no comprehensive understanding of epigenetic landscapes (e.g., long non-coding RNAs, histone modifications, and DNA methylation) that persistently modulate ferroptosis-related genes during the chronic phase
Therefore, the one-way ANOVA (one-way analysis of variance) test was preferred for statistical analysis
150 In addition to reducing fever and physical pain, acetaminophen has a profound effect on adult brain function, blunting the response to both negative and positive stimuli, including threatening stimuli, 151,152 and reducing behavioral responses to social rejection
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