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PLOS Med 5:13571371 Brownson RC, Alavanja MCR, Caporaso N et al (1998) Epidemiology and prevention of lung cancer in nonsmokers

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cost of refinancing existing debt upon maturity, is higher than average cost of debt, then upon refinancing, the average cost of debt would increase and vice versa

Segmented regression models were optimized via grid search to minimize the mean squared error (MSE) and further validated by Monte Carlo permutation tests, this approach is commonly employed in authoritative studies on the global epidemiology of other cancers (17)