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In the same dataset, 47 repair-related genes were turned up by at least 50%, while only five were turned down. GHK-Cu also appears to support antioxidant activity and helps cells handle copper more safely, which matters because unregulated copper contributes to the kind of oxidative stress linked to visible aging. Its effects reach beyond the skin, too

Everaert I, Mooyaart A, Baguet A, Zutinic A, Baelde H, Achten E, et al

The pH conflict between L-ascorbic acid and GHK-Cu means they each perform best with separation