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Activation of the nuclear factor erythroid-2 related factor-2 (Nrf2) pathway involves the transcription of multiple (antioxidant) proteins, including heme oxygenase 1 (HO-1) and NAD(P)H: quinone oxidoreductase 1 (NQO-1), which protect cells from ROS- and cytokine-induced damage and cell death

Normally, antioxidants such as glutathione, catalase, and superoxide dismutase extinguish these sparks before they cause harm

Research over the past two decades has shown that microbiome composition can influence: Energy extraction from food Fat storage signaling Immune activity Hormone production related to appetite Some microbial populations are associated with increased energy harvest from dietary carbohydrates, which may contribute to weight gain in certain individuals

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