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Gabe Mirkin is a Villager

And so when you have a closed system, you essentially just end up accumulating a lot of those metals over time, and you end up with higher concentrations in the aerosol that people breathe, he tells Rolling Stone

In contrast, when silencing NLRP3 or ASC in endothelial cells by RNA interference experiment, these cells became immune to nicotine-induced pyroptotic death, suggesting that NLRP3 inflammasome is required for nicotine-induced pyroptosis in HAECs