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240 It has also been shown that MTA accumulation and secretion occur in MTAP-deficient GBM, but no significant MTA accumulation was detected in vivo because the stromal cells in the TME express WTAP and consume the MTA emitted by tumor cells and increase the activity of PRMT5

NFIL3 (also known as E4BP4), a basic leucine zipper transcription factor, is a critical regulator of NK cell development through its induction of the transcriptional inhibitor Id2 (refs 33,34)