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With technological advancements, it is possible to design nanoparticles to be able to traverse the blood-brain barrier, increase cellular absorption, and give protection against enzymatic degradation, all of which make them an attractive candidate for delivering siRNA to the brain

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In contrast, fetal muscle showed no changes in mitochondrial activity but displayed reduced expression of genes involved in fat metabolism and energy production, suggesting early transcriptional changes that could affect postnatal muscle energy utilization (Safain et al., 2025)