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Neuron 86 , 13041316 (2015)

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5-Amino-1MQ was identified as a potent NNMT inhibitor in work published by the Bhatt Lab and collaborators, with subsequent preclinical studies demonstrating that NNMT inhibition in diet-induced obese mice reduced body weight, decreased adipose tissue mass, and improved metabolic parameters including insulin sensitivity and plasma lipids

The results indicated that N-terminal modifications were particularly effective at enhancing metabolic stability, whereas C-terminal amidation offered more modest protection