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Progression through various disease stages in cirrhosis is fraught with complications related to portal hypertension and chronic liver failure, such as acute variceal bleeding, ascites, hydrothorax, hepatic encephalopathy (HE), life-threatening infections, and extrahepatic organ failure, such as hepatorenal syndrome and additionally, hepatocellular carcinoma (2)

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However, NPs usage has certain challenges, such as including ROS-induced toxicity, abnormal internalization into tissues, and aggregation

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