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Interestingly, animals like salamanders and axolotl are able to regenerate entire limbs, and this regenerative process is driven primarily by hematopoietic and myeloid stem cells, which in the human is the equivalent of bone marrow stem cells that drive mesenchymal cell lineages of ligament, cartilage, muscle, bone, and connective tissues [52]

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[ 468 ] However, oxidative stress modifies the cysteine residues of KEAP1, resulting in its inactivation under oxidative stress