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Design of acid-activated cell-penetrating peptides with nuclear localization capacity for anticancer drug delivery

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Constipation affects 2-4% of gabapentin users according to clinical trials, making it a recognized but less common side effect compared to dizziness (28%) and drowsiness (21%)

nNOS: a neuronal cytosolic variant commonly localized to post-synaptic densities, and generally accepted to be the most involved enzyme in physiological co-transmission iNOS: a cytosolic variant expressed in a range of cells including transmission-relevant astrocytes and microglia, from which it likely plays an indirect co-transmission role eNOS: a primarily endothelial membrane-localized variant that is likely the least relevant for co-transmission NOS synthesizes NO by deiminating L-arginine into L-citrulline, short circuiting the urea cyclewhen it is present