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Ethics statement The animal study was reviewed and approved by the Animal Care and Use Committee of Al-Zaytoonah University of Jordan

2 Intake of vitamin E 2.1 Dietary intake of vitamin E There are two ways to express the dose and the amount of fat-soluble vitamins in a product: one way is based on quantity, where the unit of measurement is mg/day and the other way is based on biological activity, where the unit of measurement is an international unit (IU)

(1998) the gold-standard comparison A 12-week randomized trial enrolled 67 women with moderate-to-severe facial aging and compared four topical formulations: a copper peptide cream, a vitamin C cream, a melatonin cream, and tretinoin

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