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MOTS-c, a 16 amino acid mitochondrial-derived peptide, is encoded from the 12S rRNA region of the mitochondrial genome

The mass spectrum of complex 2 displayed one signal with moderate intensity corresponding to the sodium adduct [M + Na] + at m/z = 376 and the another signal with high intensity corresponding to the [M L] + at m/z = 254, indicating the loss of one acetyloacetone ligand

Chronic oxidative injury modifies membranes, denatures proteins, and induces strand breaks in DNA that can result in cell death or erroneous repair that causes dysfunction

The final experimental group was treated with only 1 mg/kg of DSIP by itself