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Elevated ROS themselves can act as signaling molecules, activating pro-inflammatory pathways, promoting cell death [110], amplifying inflammatory responses [111], and causing tissue damage [112]

Likewise, vitamin C can get neutralized and lose its potency

This is significant because, as further detailed below, the peripheral administration of APAP is linked to concentration-dependent in situ effects in the brain 17 , which could explain our observation of cognitive impairment and brain abnormalities with mild changes in the periphery even long after the final episode of hepatotoxicity

Vitamin D is one of the vital micronutrients