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Powder Technol 320:483497

Preclinical studies and clinical trials suggest that antioxidants, such as small thiol molecules (N-acetyl-L-cysteine and carbocysteine), antioxidant enzymes (glutathione peroxidases), activators of Nrf2-regulated antioxidant defense system (sulforaphane), and vitamins, for example, C, E, and D, enhance the endogenous antioxidant system and reduce oxidative stress

A multimodal approach targeting the autoimmune nature of the disease, activation of melanocyte regeneration, and reducing oxidative stress often has a favorable response in most patients

Liu K, Liu Q, Yang J, Xie C, Wang S, Tong F, et al