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Continuous microtrauma caused by physiological activities such as toothbrushing and mastication renders the gingival crevicular fluid (GCF) a filtrate rich in hemoglobin ( 2+ ( 2+ release, thereby forming a positive feedback loop of hypoxia-reinforced iron capture

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The DDD-Ube2e2-COP1-c-Jun complex co-expressed with STK40 exhibited an overall structure similar to that without STK40, with an additional weak density localized to the COP1 dimerization region (Supplementary Figs