Whether the research focus is metabolic, body composition, or exploratory, the core principles remain: Start low: 0.5 to 1 mg is a safe starting dose
216 Mutations relevant to ASD typically sensitize voltage-dependent Ca 2+ channel gating, shifting their activation to more hyperpolarized potentials of ~10 mV
Investigations are guided by clinical suspicion rather than routine panels: for example, thyroid function tests and ferritin may be checked if symptoms suggest deficiency or thyroid disease, while an androgen profile may be appropriate in women presenting with menstrual irregularity, hirsutism, or acne
15 Because serum methylmalonic acid level is as sensitive as, but more specific than, serum homocysteine level for vitamin B 12 deficiency, it is the confirmatory test of choice