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Compared with control cells, the mRNAs of ACC (acetyl-CoA carboxylase), CHOP (CCAAT/enhancer-binding protein homologous protein) and caspase -3 significantly increased and PPAR - (peroxisome proliferator activated receptor ) mRNAs significantly decreased in the alcohol-induced model groups of human normal liver cell line LO2 (Figure 7A), hepatocellular carcinoma cell line HepG2 (Figure 7B) and model animal (Figure 7C)

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Keap1 decreases in response to low intensity stimulation, releasing the inhibition on Nrf2 and resulting in increase in Nrf2 activation and ARE binding in low intensity stimulation

Notably, BACH1 is traditionally recognized as an angiogenesis inhibitor that regulates HO-1 or VEGF transcription