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Nasal sprays may come in fixed concentrations (for example 50 mcg per spray) and may require adjusting number of sprays rather than volume

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NAD+ levels decline approximately 50% between ages 40 and 60, which correlates with increased systemic inflammation (often called "inflammaging")

In general, dose selection for an elderly patient should be cautious, usually starting at a low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or drug therapy