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TRPV1 is expressed in about 60% of vagal neurons, and TRPA1 in about 25%.[ref] In addition to chemical stimuli, TRP receptors respond to oxidative stress and systemic inflammation.[ref] Repeated activation and hyperexcitability: TRPA1 and TRPV1 receptors are often co-localized on the same cells

doi: 10.1038/s41574-021-00553-7

However, "reversing" osteoporosis is not a realistic claim, as these should be considered complementary to conventional treatment rather than standalone therapy