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Pharmaceutical companies, payers and health systems will have to adapt to whatever regulatory framework emerges

Animal studies have demonstrated that the administration of pyruvate, the end metabolite of glycolysis, can achieve neuroprotection by normalizing metabolic disturbances and antagonizing zinc neurotoxicity following global ischemia (16)

It is important to note that this alteration not only potentially increases its stability but also may affect how it interacts with other cellular components compared to its natural counterpart

In certain conditions where neutropenia is expected, such as chemotherapy, granulocyte colony-stimulating factors (eg, filgrastim [Neupogen]) and/or granulocyte macrophage colony-stimulating factors (eg, sargramostim [Leukine]) can be used as a preventive measure (Renner 2012)