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Composed of the light chain subunit solute carrier family 7 member 11 (SLC7A11) and the heavy chain subunit SLC3A2, System Xc imports extracellular cystine, which is then rapidly reduced to cysteine intracellularly (28)

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Chen Y, Yang S, Kong H, Wang Q, Chen S, Wang X et al (2023) Oxalate-induced renal pyroptotic injury and crystal formation mediated by NLRP3-GSDMD signaling in vitro and in vivo