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Figure 1 Cytochrome P450-Mediated Metabolic Activation APAP metabolic activation is mainly catalyzed by the cytochrome P450 enzyme and the reactive metabolite associated with hepatotoxicity is commonly considered to be NAPQI (Jollow et al., 1973)

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A critical dinucleotide coenzyme that activates sirtuins and supports mitochondrial function, studied for cellular energy metabolism in research models