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Infiltrating leukocytes such as tumor associated macrophages (TAMs), neutrophils, dendritic cells, and lymphocytes establish an inflammatory microenvironment and are key components in tumors of epithelial origins

Although used for centuries as an ingredient in Asia, most forms are poorly absorbed in the bloodstream, whether coming from food or a nutritional supplement

Acknowledgements We sincerely thank Hua Hua, Anqi Zeng, Li Liu, Weiwei Tian, Ruirui Wang, Lei Zhang, and Junning Zhao for providing guidance and assistance on this paper

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