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however, age over 65 may be associated with a greater incidence of central nervous system depression and more respiratory depression (see WARNINGSPreanesthetic Use , PRECAUTIONSGeneral and ADVERSE REACTIONSPreanesthetic)

Lee JW, Kim Y, Kim Y, Yoo H, Kang HT (2020) Cigarette smoking in men and women and electronic cigarette smoking in men are associated with higher risk of elevated cadmium level in the blood

By the turn of the twentieth century, North Carolina was internationally recognized as America's leading source of tobacco