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What to avoid when taking glutathione To get the most from glutathione, it helps to reduce the things that deplete it: Alcohol heavily depletes glutathione and burdens the liver Smoking a major source of oxidative stress Excess processed and fried food increases free-radical load Poor sleep and chronic stress both lower natural production There aren't many strict "don't combine with X" rules for healthy adults, but if you take regular medication, have a medical condition, or are pregnant or breastfeeding, talk to your doctor first (see disclaimer below)