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In addition to vasoconstriction, carbon monoxide from cigarette smoke decreases the oxygen carrying capacity of blood
(2) reporting a serious, unstable psychiatric condition (e.g., bipolar disorder, schizophrenia), (3) reporting a serious, unstable physical health condition that would increase risk of study participation determined by medical history interview and review by study physician (e.g., past or present cardiac problems, respiratory problems, overnight hospitalization in the past 3 months), (4) current criteria for DSM-5 moderate or severe cannabis use disorder, (5) current use of other psychoactive substances confirmed by urine drug screening, unless prescribed and stable for 2 months, (6) living with someone who currently smokes menthol cigarettes, to reduce access to preferred cigarettes during the switching phase of the study, consistent with our pilot [19], (7) known allergy to PG/VG in e-liquid, (8) female participants will be excluded if they are currently pregnant, planning to become pregnant, breastfeeding, or unwilling to use an effective method of birth control for the duration of the study, (9) abnormal spirometry test, (10) if reporting recent cannabis vaping (past 90 days), additional exclusion will be any report of mild or greater EVALI-related symptoms (e.g., cough, shortness of breath, chest pain) without non-EVALI reasonable and proximal cause
While some studies reported adverse effects with reduced clinical pregnancy rates 33,34 , increased abortion rates 33,53 , fewer oocytes per OPU 42,54,55,56 , lower fertilisation rates 54,57 , reduced endometrial thickness 37 , higher gonadotropin dosages for ovarian stimulation 58 , and increased cytoplasmic and meiotic anomalies 55,59 , others did not confirm these findings
