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Alcohol acts on neurotransmitter receptors, including GABA, glutamate, and dopamine, with each receptor contributing to various physiologic effects, with chronic alcohol administration increasing tolerance and addiction (Mann et al., 2001

Mitochondrial damage is often defined as a deviation of respiratory parameters or states, which were originally defined in vitro using isolated mitochondria 80,81,82

Joint injection should be considered after other therapeutic interventions such as nonsteroidal anti-inflammatory drugs, physical therapy, and activity-modification have been tried