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Acknowledgements This work was supported by the Israel Science Foundation founded by the Israel Academy of Sciences and Humanities, grant number 419/15 and by the Gurwin Fund for Scientific Research

The peptide is available in a convenient nasal spray format, having been shown to deliver effects in as little as 30 minutes

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In this study, the intestinal microenvironment was recapitulated by applying defined mechanical deformations and fluid hydrodynamics, exploiting a coculture with a host microbiome while allowing the real-time monitoring of cell morphology and cell-cell interactions, in a manner not possible with a standard organoid culture