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When commencing B12 replacement therapy, it is essential to recognise that pre-existing joint conditions will not resolve with vitamin supplementation alone and may require separate rheumatological assessment and management according to NICE guidelines

Lin WY, Li LH, Hsiao YY et al (2022) Repositioning of the angiotensin II receptor antagonist Candesartan as an anti-inflammatory Agent with NLRP3 inflammasome inhibitory activity

Centella Asiatica Leaf Extract rounds out the formula by soothing sensitivity during the brightening process

The study aims to clarify the structural and functional aspects of how this antivitamin interacts with CblC, which is crucial for converting vitamin B12 into its active forms