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A 2019 safety review examined 87 human studies on natural astaxanthin including 35 using doses of 12mg per day or higher and found no significant safety concerns or consistent adverse effects.11 Across those trials, approved or studied doses commonly ranged between 2mg and 24mg per day, and higher short-term doses (up to 40mg per day for several weeks) have also shown good tolerability in adults, with no serious events reported

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[DOI] [PMC free article] [PubMed] [Google Scholar] 10.Coleman M., Blass J.P

Further research has revealed that, with the assistance of the coactivator PGC-1, FOXO1 regulates glycogenolysis and gluconeogenesis by modulating the expression of G6PC and PCK1