Importantly, in addition to the N-terminal cytosolic tail of GNPT interacting with COPI, the cytosolic tails of LYSET associate with the COPI adaptor GOLPH3 and retromer to maintain the LYSET-GNPT complex at the Golgi
This is because glutathione is a very powerful anti-oxidant which helps limit cell damage from harmful byproducts produced by normal body metabolisms and disease
Zhang X, Zhang R, Ren C, Xu Y, Wu S, Meng C, Pataer A, Song X, Zhang J, Yao Y, He H, Chen H, Ma W, Wang J, Meric-Bernstam F, Champlin RE, Heymach JV, Rooney CM, Swisher SG , Vaporciyan AA, Roth JA, You MJ, Wang M, Fang B
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