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12 6 1217 H Zhang P Zhabyeyev S Wang 1865 Role of iron metabolism in heart failure: From iron deficiency to iron overload Biochim Biophys Acta (BBA) Mol Basis Disease 7 1925 1937 J-C Lousse S Defrre A Langendonckt Van J Gras R Gonzlez-Ramos S Colette 2009 Iron storage is significantly increased in peritoneal macrophages of endometriosis patients and correlates with iron overload in peritoneal fluid Fertil Steril 91 5 1668 1675 JD Puentes-Pardo S Moreno-SanJuan Carazo J Len 2020 Heme oxygenase-1 in gastrointestinal tract health and disease Antioxidants

102 MasudaS.KurabayashiN.NunokawaR.OtobeY.Kozuka-HataH.OyamaM.et al (2024)

Specifically, downregulated heat shock protein A12A (HSPA12A) in hepatocytes increases glycolysis and lactate production, which leads to HMGB1 lactylation and exosomal secretion of hepatocytes, exacerbating hepatocyte damagemacrophage chemotaxis/activation

By the time the boy was eight, the resemblance had become unmistakable, and he assumed financial responsibility for him and his mother but kept the secret until challenged directly in a therapy session