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First, because cigarettes are designed to create and maintain addiction, the FDA should limit the amount of nicotine that they contain to a level at which they would cease to be addictive

Sample size calculation The required sample size was estimated to be 363 (min 272) based on the prevalence of IBS in the general population being estimated to be 13% with an estimated error of 4%, Type 1 error (alpha) 5% (two-tailed), power 95%, and allowing for a 25% dropout rate

Illicit Trade Control Measures 6

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