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Additionally, tools including AbSRA and NovoPro were used to identify the complementary determining region (CDR) regions, which are not ideal sites for incorporating ncAA due to the risk of impacting binding affinity

J Biol Chem 273:2449124497 Solodkin A, Traub RJ, Gebhart GF (1992) Neuroscience 51:495499 Song P, Wu Y, Xu J, Xie Z, Dong Y, Zhang M, Zou MH (2007) Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner

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