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The skin appears healthy all over the body

This often-misdiagnosed condition affects the small, unmyelinated nerve fibers responsible for pain, temperature sensation, and autonomic functions, leading to symptoms that can range from mild discomfort to debilitating pain and dysfunction

Furthermore, this study also confirmed that liproxstatin-2, a new ferroptosis inhibitor, possessed a prophylactic and therapeutic benefit in alleviating LN patient serum-induced renal tubular epithelial cell ferroptosis[158]

Taken together, ceramide-mediated PS exposure and cell shrinkage are one of the best-documented signaling pathways leading to erythrocyte death and efferocytosis of eryptotic cells