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If a product is contaminated with impurities, fillers, or synthesis byproducts, its pharmacokinetic profile can become completely unpredictable

Mol Biol Rep

We recently observed that mice lacking the M 1 muscarinic acetylcholine receptor developed RGC loss at advanced age, which went along with elevated ROS levels and increased mRNA expression for the prooxidative enzyme, NOX2, but decreased mRNA levels for the antioxidant enzymes, SOD1, GPx1 and HO1, suggesting that the M 1 receptor is involved in modulating redox pathways in the retina [436]

Therefore, it is prudent to identify what impact cannabis use has on the integrity of myelin in the aged brain in order to propose harm reduction strategies if needed