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Amylin and Cagrilintide activate CGRP-like neurons in the AP that project to: Nucleus tractus solitarius (NTS) , autonomic center Parabrachial nucleus , integration of taste and satiety Hypothalamic pathways , energy balance The result: strong central appetite suppression and stabilization of satiety between meals

Oral versions such as capsules or troches are more convenient, but absorption through the digestive tract is far less consistent, so the amount that actually reaches circulation can vary widely